ANN ARBOR, Mich.-University of Michigan biological chemist Ray Trievel and two scientists at Luminos LLC have filed a patent application for a novel method to detect enzymes that can alter DNA molecules, sometimes leading to the onset and progression of various cancers.

Demethylase enzymes remove methyl groups attached to DNA, proteins and toxins. They have become a target of intense interest among biomedical researchers.

The two known classes of demethylase enzymes produce formaldehyde as the product of

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